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Originally Posted by
me2
As far as I know there has not been a study of Dapsone related to wg. Of course your doctor is using the logic that treating PCP with Dapsone is the same as using Bactrim. It might be. But one thing this illness has taught me is to rely on studies when I can and to be leery of logic. It often defies logic. I don't understand why your doctor would 'not be interested' in a desensitizing protocol that would give you the well studied drug Bactrim to have in your weggie defense tool box. Lazy? I dunno
The protocol is inexpensive, easy, safe and takes only a couple of weeks to find out if you will be successful in taking Bactrim. Bactrim is cheap and well tolerated by most. It has a very high success rate. I don't see why someone wouldn't be interested in adding such a proven tool to your treatment. Just my opinion too. ha
Way back in the dark ages of WG treatment I found out about Bactrim from the person who discovered its utility - Dr DeRamee. This was before any studies had been done.
I met him at one of the Vasculitus conferences many years ago. Even he did not know about the desensitization protocol at that time. I came home and found it through research on my own. I took it to my doctor, who had never heard of it, and went through it. I can now take bactrim no problem. Its a good tool to have.
I tried the desensitization protocol. It would have taken three weeks to complete it but the doctors called it off on day two due to the reaction I was having to two drops of the suspension in a glass of water. A normal dosage would have been 20 drops I believe. I was doing it at the clinic in the office of a doctor who treated allergies. You need to have access to epinephrine in case of any serious reactions when trying any desensitization procedure. My allergy is due to the sulfa part since I take the other part of Bactrim which is trimethoprim without any problem. Bactrim though is 5 parts of sulfamethoxazole to one part of trimethoprim.
Dapasone caused a blood anomaly for me. I had anemia at the time and it was unclear if the Dapasone contributed to it of if the broken blood cells from Dapasone happened because of the anemia. Anemia is one of the contraindications to Dapasone I had along with diabetes and allergy to Sulfa drugs. People on MTX may also have problems with it.
Last edited by drz; 01-09-2014 at 04:41 AM.
Knowledge is power! Wisdom is using it to make good decisions!
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