Middlesista: you may find the following links useful as a start:
PR3 - Clinical: Proteinase 3 Antibodies, IgG, Serum
How Rituxan Is Thought to Work - RituxanŽ (rituximab)
Essentially, ANCA are produced from plasma which, in turn, originates from B-cells. Rituxan destroys B cells, so ANCA production stops. The PR3 test measures antibodies that target the proteinase enzyme (C-ANCA does). Typically, the ANCA test is done once, during diagnosis. Once determined to be C-ANCA, after treatment the PR3 levels are tested. As the second link says,
"
The levels of PR3 ANCA often decline following successful treatment of patients with WG. Nevertheless, follow-up testing for PR3 ANCA to evaluate clinical status in treated patients should be used with caution as the levels of antibodies may correlate poorly with clinical status in some patients."
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