Weggie's Lounge Update

[crowneagle]

I disconnected from Facebook but continue on with my WG discoveries.

Over the past few years, I've been debilitated with bouts of pancreatitis and bowel problems. Recently, I discovered the statin drug I was taking might be the cause of my immune battles. My gastroenterologist told me that Rituximab may cause bowel issues. I took it one step further and found out RTX and statin drugs both suppress IL-10, a major anti-inflammatory cytokine. IL-10 suppresses T cell immunity and helps create immune tolerance. Since going off my statin drug, I've had no further problems thus far. Weggies are just built differently than most people.

Secondly, the Broad Institute in Boston, recently did a study, using connectivity maps, to determine substances most effective in Anca Associated Vasculitis. The most effective compound was fisetin, a flavonol, derived from strawberries. "Connectivity Map analysis indicated the most significant compound was fisetin." Happens to be I've been using fisetin for five years. I chose it because it was one of the only substances that acted as a natural systemic immune suppressant, suppressing both th1 and th2 immunity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897842/ Always talk to your doctor, before considering supplements.

The Broad Institute has a discovery center in Boston and gives tours for those interested in their work. https://www.broadinstitute.org/broad-discovery-center