Methotrexate

[Brooke]

How long before Methotrexate is supposed to start working?

[Sangye]

I've been told that all the non-pred drugs take at least a month to fully kick in.

[katwoman]

Hi Brooke, I've been on Methotrexate for six weeks, my joint pain eased up after 4-5 weeks on the medication, so I am hoping that is a good sign WG is getting under control.

How long have u been on the methotrexate? My Rheumy did say it could take up to 12 weeks for improvement to manifest itself.

I have another question to add - my Rheumy has just put me on a course of Penicillin for throat infection and the chemist seemed to be concerned about the interaction between that and Methotrexate and advised me to be careful of any side affects I may experience, has anyone else been on both?

[elephant]

Penicillins may increase methotrexate level. Which can cause methotrexate toxicity. So call your doctor to let him/her know and get some labs done. Need to check your methotrexate and liver enzymes at least.

[Brooke]

I have been on Methotrexate not quite 2 months. I am feeling a little better overall but not there yet.

[jola57]

Brooke, have you taken cyclophosphamide before taking mtx

[fester500]

I increased my methotrexate dose gradually - I started on 10mg a week and it took about 2 months to get up to 20mg. Once I got to 20mg, my doctor said it would take up to three months for me to see the effects. I'm not sure yet if it is working for me.