My dad was diagnosed with wegener's 10 years ago and was in remission with rituxan for 8. Over Xmas doctors discovered a build up in his lungs after his 'sickness' wasn't clearing up and it was determined by his doctor he was 'flaring'. Shortness of breath, coughing, and fatigue are the most obvious symptoms. Apparently the rituxan isn't working anymore...anyone else ever here of this/have flared with rituxan? He has been on cellcept, methotrexate, cytoxan, and is now trying imuran. He sees a rheumatologist in Marshfield, WI, but is working on heading to Cleveland Clinic for hopefully more answers as to what is going on. We have been so appreciative of the 8 years of relatively good health, and are scared with what we are seeing now. Any help or input would be great, thank you!