Hello Stephen!
I asked the same question of my doc at Cleveland Clinic. She said that 15 mg/wk is the lowest effective dose. She went on to say that those who go off mtx without any other maintenance meds have a 40% chance of a flare within a year.
I went off mtx in August, but had four infusions of rituximab immediately following. So far, so good. The main reason I went off mtx is that the side effects were increasing and starting to interfere with my life activities. I was to the point where I was kinda wiped out for 2-3 days following each week's dose.
Pete
dx 1/11
"Every day is a good day. Some are better than others." - unknown
"Take your meds as directed and live your life as fully as you can." - Michael Chacey, MD
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