Hi everyone - I haven't posted in a while and just had my rheumy appointment yesterday. To quickly recap my situation, I have had two surgeries to remove lung nodules in the past ten years following episodes of coughing up blood, with no actual diagnosis until January 2009, but no medication regimen. After the appointment in January, my doc said that we would see what my blood tests did over the next three months and go from there. Results yesterday showed that my ANCA level is up from 127 to 275. All my other blood work was fine. The only symptoms I am currently experiencing are fatigue, headaches and occasional swelling in my joints. Both my doc and the specialist he is working with suggest I start Methotrexate to keep my ANCA level from going up anymore and to keep more severe symptoms at bay. So any input on this suggestion? What could I expect from the Methotrexate? Thanks!