great news, Psyborg. I have been on mtx since March (upped dosing once) and haven't experienced a single side effect (so far). I also have perhaps one drink a week -- my doc does not forbid it (and in fact, the researchers at the Symposium said only American docs tend to forbid it, French docs think a glass or two of wine/week on mtx is completely acceptable as long as your liver enzymes remain stable).