Hello all, so glad to find this forum. I am writing on behalf of my 85 year old mother-in-law who was diagnosed with Granulomatosis GPA in December 2022. This after months of debilitating sinus problems - bloody clots, difficulties breathing and sleeping.. finally an ENT specialist did a biopsy and blood results showed Wegeners. The rheumatologist prescribed Methotrexate but Hilary was unable to handle the side effects (including severe vertigo) and stopped after 2 weeks. At the moment she is taking only piroxicam (daily) which is helping with some of the inflammation (swollen ankles, sore gums, etc). However, she is becoming increasingly frail and fatigued. We just read about Rituximab (yes waiting for specialist appointments there is plenty of time to read the internet). We are wondering if this a possible alternative to Methotrexate..? maybe in a different family so side-effects may not be as severe..? Not trying to bypass the specialists by any means, but I guess we are all a bit confused about whether these drugs treat the original condition (Wegeners) or simply the symptoms..? Very happy that this forum is available to be able to connect with people with first-hand experience. We just don't know what to expect with this disease. Best wishes and Happy New Year to you all. Marg.