Evusheld

[Middlesista]

From what I have read “Monoclonal antibodies are laboratory-produced molecules that act as substitute antibodies that can restore, enhance or mimic the immune system's attack on cells.” For those of us on Rituxin which works to shut off our immune response, to some degree, by affecting our B cells - what effect will Evusheld have on our GPA?

[Dirty Don]

Got my Evusheld shot yesterday. Was randomly selected as Mayo has only 400 shots of it. Should head to Vegas next I guess. Felt fine during the rest time afterwards, but by time I got home I was very tired. Rested most of afternoon, slept well last nite, and feel good this AM. No symptoms today...NEXT!

[drz]

Does Evusheld have any risk of causing a flare of GPA like the vaccinations did for me? I don't dare get any boosters since the first two vaccinations seemed to cause a serious flare of my GPA that did a lot of damage to my lungs and body. I would try the Evusheld if it would be safe for me to take.

[Pete]

The explanation I was given for how Evusheld works follows. It prevents the spike proteins in the Covid virus from attaching to other cells, thereby facilitating the elimination of the virus from the body. Evusheld complements the body’s natural immune system. A Covid antibody test performed on a person who has received Evusheld is not likely to show any Covid antibodies as the monoclonal antibodies aren’t detected by this test.

That said, I have had two half doses of Evusheld with no obvious side effects. I suppose there is a small probability that Evusheld could trigger a GPA flare. I’m not aware of anyone who got Evusheld having a subsequent flare. See what your GPA doc says and proceed accordingly. Good luck!

[drz]

The explanation I was given for how Evusheld works follows. It prevents the spike proteins in the Covid virus from attaching to other cells, thereby facilitating the elimination of the virus from the body. Evusheld complements the body’s natural immune system. A Covid antibody test performed on a person who has received Evusheld is not likely to show any Covid antibodies as the monoclonal antibodies aren’t detected by this test.

That said, I have had two half doses of Evusheld with no obvious side effects. I suppose there is a small probability that Evusheld could trigger a GPA flare. I’m not aware of anyone who got Evusheld having a subsequent flare. See what your GPA doc says and proceed accordingly. Good luck!

My doctors have said it should be safe. The other question I had was if it would be effective for me if I was taking Avacopan and Azatioprine to control my GPA? But that risk has little downside so I will pursue getting it.

[drz]

How much hassle was it to get Evusheld? How long did it take to get approved to get it?

[Pete]

As I write this during day 3 of Covid, I could have gone all day without reading this: https://amp.cnn.com/cnn/2022/09/07/h...4-6/index.html

I started having symptoms on Labor Day evening — sore throat, greater than notrmal sinus drainage, and low grade fever. My wife took a Covid test Tuesday morning and called her PCP, right away. She got bebtelovimab yesterday. I called my PCP on Tuesday afternoon and she called in a Rx for paxlovid which I started Wednesday. I think I’m feeling better (read that as just a little less crappy), but still have way to go. Temp fluctuates between 100-101, sore throat, fatigue, no energy. Hope it doesn’t get worse…

[Dirty Don]

Hang tough my friend, another bump, you'll get past this one too.

[Pete]

This just in …

https://www.cnn.com/2023/01/26/healt...ion/index.htmlWith rise of new coronavirus variants, FDA halts authorization of Evusheld