My GPA experience started in December 2016 when I started having night sweats every night. Not just a little night sweat. But the kind of night sweat that soaks your clothes and bed clothes. I felt bad, had no energy, and had no desire to eat. Then I developed clogged sinuses. I thought I had a nasty head cold. Then in January 2017, after almost passing out at home, the local ER diagnosed me with a PE in each lung. (I was prescribed Eliquis.) Why would that have happened? Up until this point in my life, I had been a healthy, active person with no heart issues. Multiple visits to multiple specialists (lung, hematology, gastroenterology, vascular) turned up nothing. I still felt bad and was losing weight, and we still didn't know what caused the PEs. Then, in March 2017, I went to the ER for something totally unrelated, and bloodwork that was done revealed that my kidneys were failing. The nephrologist at the hospital suggested an ANCA test, and I was then diagnosed with GPA. A kidney biopsy confirmed it. Rituxan smacked it down, and I have been in remission for 2+ years, and now my PR3 level has started creeping up. I've been feeling good, but that has me concerned. All other labs are fine, but the PR3# is increasing slowly. I take 15mg methotrexate. Has anyone else had this happen (creeping PR3)? I'm happy to have found this forum. I don't know anyone who had ever heard of vasculitis before!