Hello All

I did get a second opinion from UCSF vasculitis specialists here in SF and the doc confirmed from the symptoms and tests that I do have GPA. While the joint pains have gone, my right eye issue with redness and pains have persisted.

I have done 4 months of Methotrexate (25 mg/week) and Prednisone from 60mg to 10mg tapered now. I followed up with eye doc specializing in inflammatory conditions and they have dx ed me with scleritis (mild). The eye docs think that this can progress pretty fast and are recommending to move to Rituxan infusion from MTX to really get a control over the eye issue.

I am still in denial and the thought of "infusion" of a new drug is weighing on my mind. Everything you read about Rituxan points to cancer - and I don't want to think about it

But ..
  • Has anyone here who has had scleritis and Rituxan experience?
  • Did it work? How quickly did it show positive effects?
  • What are the side effects of Rtx compared to Mtx? How concerned should i be?