User Tag List

Likes Likes:  678
Page 24 of 24 FirstFirst ... 14222324
Results 231 to 233 of 233

Thread: Coronavirus and GPA

  1. #231
    Join Date
    Jul 2010
    Location
    see map location in MN
    Posts
    4,278
    Post Thanks / Like
    Mentioned
    12 Post(s)
    Tagged
    0 Thread(s)

    Default Re: Coronavirus and GPA

    I think my GPA was smoldering before the Covid 19 vaccine checked it into a more serious flare. I had never been able to get back to my basic maintenance meds of 5 mg of prednisone after a couple of hospital stays for pneumonia. The 60 mg of prednisone seems to have eliminated any nosebleeds and clots in my sinus rinse as well as getting rid of the inflamed eyelids which required me to take Restasis meds a couple times a day. My overall muscle aches and pains and sore joints also improved greatly although I still have some pain in one hip which may or may not be related to the GPA flare.

    I hope after I finish the rituximab treatment I will be able to get back to a more stable drug induced remission. I would also like to get tested to see if I developed any immunity to the Covid 19 virus after getting both Moderna shots.

    I wonder how many people with autoimmune disorders were pushed into a flare or exacerbation of their autoimmune disorder.
    Knowledge is power! Wisdom is using it to make good decisions!

  2. Likes Masha, [email protected] liked this post
  3. #232
    Join Date
    Mar 2017
    Posts
    220
    Post Thanks / Like
    Mentioned
    5 Post(s)
    Tagged
    0 Thread(s)

    Default Re: Coronavirus and GPA

    My wife and I are going on a road trip tomorrow. We’ve been home bound since the virus began but a grandson is graduating high school in Texas. This will be over 2000 miles round trip. It’s scary but I think that it’s time.

  4. Likes Pete, Masha liked this post
  5. #233
    Join Date
    Jul 2010
    Location
    see map location in MN
    Posts
    4,278
    Post Thanks / Like
    Mentioned
    12 Post(s)
    Tagged
    0 Thread(s)

    Default Re: Coronavirus and GPA

    How many people have been tested after the Covid-19 vaccination's to find out if they developed adequate protection tool Covid-19? How important is it for us to do so? Any information on how valid these tests are for us?

    MAY 12, 2021



    Study suggests rituximab associated with impaired serological response to COVID-19 vaccination in patients with rheumatic diseases



    Rituximab, but not other antirheumatic therapies, was associated with impaired serological response to coronavirus disease 2019 (COVID-19) vaccination in patients with rheumatic diseases, according to a study published in Annals of the Rheumatic Diseases.
    “There is a paucity of data on the effect of antirheumatic drugs on serological responses to COVID-19 vaccines. Anti-CD20 therapies deplete B-cells, with reconstitution often not beginning for 6–9 months after infusion, resulting in diminished humoral immune responsiveness to recall antigens,” wrote Robert Spiera, Hospital for Special Surgery, New York, New York, and colleagues.
    For the study, researchers retrospectively analysed data of 89 adult patients from one rheumatology practice who had received at least one dose of COVID-19 vaccine. All patients had a clinic visit from February 24 to April 8, 2021 and were serologically screened for antibodies to the severe acute respiratory syndrome coronavirus 2 Spike protein.
    Of the patients, 83 (93.26%) had received both doses of a COVID-19 vaccine at the time of immunoassay. Further, 30 patients (34%) were treated with rituximab, while 35 patients (39%) were taking more than one antirheumatic medication at time of assessment.
    Among patients treated with rituximab, the median time from the last rituximab exposure to the time of immunoassay was 212 days, whereas the median time from the last rituximab exposure to the second dose of COVID-19 vaccine was 167 days.
    Overall, 68 patients had a positive antibody response and 21 had a negative antibody response. Most of the patients with serologically negative results were patients using rituximab (20/21), with the only other serologically negative patient having been treated with belimumab.
    Among rituximab users, the researchers found that those with a positive serological response had a longer time from the last rituximab exposure to receipt of first COVID-19 vaccine dose compared with those with a negative response (median, 704.5 days [interquartile range {IQR} 540–1,035] vs 98 [IQR 64-164) days]; P < 0.001). Further, among 11 rituximab-treated patients with data available for B-cell reconstitution, 4 were serologically negative and 7 were serologically positive. The median percentage of B-cells among those with negative serological response was 0 (IQR 0–0.15), while the percentage among those with positive serological response was 4 (IQR 1.2–10).
    “In this study, all patients who did not demonstrate a positive serological response had been treated with rituximab, with the exception of one patient that was treated with belimumab, another B-cell targeting strategy,” the authors noted. “Longer duration from most recent rituximab exposure was associated with a greater likelihood of response. The results suggest that time from last rituximab exposure is an important consideration in maximising the likelihood of a serological response, but this likely is related to the substantial variation in the period of B-cell depletion following rituximab … Confirming B-cell reconstitution before vaccination may increase the likelihood of a positive serological response.”
    “These data, if confirmed in larger cohorts, could have important clinical implications regarding timing of vaccination in rituximab exposed patients. In communities with limited access to COVID-19 vaccines, confirming B-cell reconstitution prior to vaccine administration may be prudent,” the authors added.




    Reference: https://ard.bmj.com/content/early/20...is-2021-220604



    SOURCE: Annals of the Rheumatic Diseases


    Knowledge is power! Wisdom is using it to make good decisions!

  6. Likes Masha liked this post
Page 24 of 24 FirstFirst ... 14222324

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •