Hi everyone,
Has anyone built up a resistance to RTX?

I?ve been on it for 4.5 years now (2000mg every 6 months) and I?ve noticed GPA symptoms come back towards the end of the 6 month intervals. My doctor mentioned something offhand about building antibodies against Rituximab and when I did research on google scholar, it seems this is the case. There is even a blood test for it called ?HACA? which I will ask for the next time I see my doctor. Have you gotten this test?

Has anyone here built up a resistance to RTX? Did you then switch to cytoxan? I?m scared that I?ll have to switch medications because RTX has worked so well for me.

Any insights would be appreciated.

Many thanks!