Male pasient and possibilities for a baby

[Bing505z]

I don’t want to be a downer and am reluctant to say this... I knew a woman who’s husband was on methotrexate (for kidney transplant- not GPA and I do not know if this is due to the methotrexate or not. However I do know methotrexate is associated with congenital abnormalities- at one point I was on it). She had 2 kids and both passed away from pulmonary hypertension. . I think it would be smart to speak to your Dr and collect information. I wish you luck!!


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Lots of info out there about this drug, and there doctor should have warned them.

Is it safe for a man to use methotrexate whilst attempting to father a child?

Methotrexate inhibits the synthesis of DNA and may cause birth defects when taken by women during certain stages of pregnancy.
There have therefore been theoretical concerns that use of methotrexate in men might cause genetic mutations (spelling mistakes in DNA) in sperm that could affect the development of a baby. It takes approximately three months for a sperm to form. Men taking methotrexate are therefore advised not to conceive for six months after stopping methotrexate. This is to allow methotrexate to be cleared from the body and for new sperm to develop in a methotrexate-free environment.
http://www.medicinesinpregnancy.org/...age=en&print=y

[Bing505z]

If you are male or female thinking about having kids and your doctor tells you need to be on prednisone, have him tell you about the affects.

For men:

http://americanpregnancy.org/getting...eption-health/

• Steroids, such as prednisone and cortisone, which are used to treat asthma, arthritis and skin conditions, impact male fertility.
• Chemotherapy and radiation could cause sterility or a significant change in sperm quality and quantity

Now for women:

Some doctors actually give prednisone to help women become pregnant, but there can be problems:

For example, suppression of the immune system through inappropriate use of these drugs is linked to impaired placental development, which in turn elevates the risk of miscarriage, preterm birth and birth defects."
Research shows that women taking corticosteroids over the first trimester of pregnancy have a 64% increase in miscarriage; the risk of preterm birth is more than doubled; and their children have an elevated risk of birth defects, including a 3-4 times greater risk of cleft palate.
"Our main message to clinicians and to women hoping to achieve pregnancy is that they should be focused on achieving good-quality pregnancy and the life-time health of the child, not just getting pregnant," Professor Robertson says.
"Corticosteroids such as prednisolone may impair healthy pregnancy, which may lead to poorer long-term outcomes for the baby"


https://www.news-medical.net/news/20...and-child.aspx

[Aneinu]

Hope all is well. We just got the news that it is now being said that one should not engage in fathering children when using cellcept.

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[Kitekite]

Thank you for your reply. We tried over 8 months, but nothing. I actually stopped trying from December because I had doubts. Even when my husband has been reducing medicines and getting so much better, I feel he is still weak. I don’t think a weak father man make a healthy baby. I went to my doctor last November and got referred to specialists. But as usual, it has such a long waiting list in this country and finally in a few weeks time my husband is getting his sperm tested with specialists. And I am going to the women’s apartment for a check in March.

[Aneinu]

Wishing you well. It is a lot to deal with.

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[Bing505z]

Rituxan also, Doc says wait 6 months to year after treatment. If male, before treatment deposit and freeze...you never know how you individually may be impacted. Females ....harvest eggs and freeze..even as a couple do IVF and harvest embryos to save for later and then start treatments. Of course each case may be different and someone may be in an urgent condition needing treatment and you have no time to take measures to protect your fertility. For those not wanting to multiply...it is of no concern.

[Aneinu]

Rituxan also, Doc says wait 6 months to year after treatment. If male, before treatment deposit and freeze...you never know how you individually may be impacted. Females ....harvest eggs and freeze..even as a couple do IVF and harvest embryos to save for later and then start treatments. Of course each case may be different and someone may be in an urgent condition needing treatment and you have no time to take measures to protect your fertility. For those not wanting to multiply...it is of no concern.

Thank you. I don't remember seeing that by rtx, but perhaps I missed it. The doctors seemed to say that rtx was an advantage over cytoxin because of this side effect, but perhaps that was on account of causing infertility.

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[Bing505z]

Thank you. I don't remember seeing that by rtx, but perhaps I missed it. The doctors seemed to say that rtx was an advantage over cytoxin because of this side effect, but perhaps that was on account of causing infertility.

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I read a thread on here going back to 2011 and one woman became pregnant soon after completing Rituxan infusion and had a completely healthy baby. She also said she had taken a lot of cytoxan. So it varies from person to person. Rituxan is said to have lower chances of cancer and infertility. Lower. If you read the insert, studies are also described as incomplete. Those studies were also performed on monkeys. Docs says they are not sure of the long term, and with fertility they are not sure and that results can vary. If a Doc says 100% it will do this or that, that Doc is a quack.