Im headed to CC friday and in my record searching i realized my PR-3 is always negative...i did'nt find a positive in all 16 years since dxed. I read that 99% of wegener patients test positive for PR-3. So im just wondering who all out there is negative? My ANCA titer is usually fairly high and my MPO is too. Funny, the MPO says its uncommon in ppl with wegeners. Im scratching my head. Just a little though.