Pete -- What dose of Septra do you take. I believe my mom is taking the 400/80 Septra (Bactrim) 3 x weekly. She is on 10 mg. of prednisone at the moment, although they want to taper down to less -- like, to maybe 5 in time. If I may ask, did you do the cyclophosphamide-prednisone treatment or Rituximab initially after diagnosis, and have you had to use other maintenance drugs, or did the Septra work all this time on its own? I was looking at a study called TAPIR in which low dose prednisone was used for maintenance and it mentions using cotrimoxazole (Septra - or Bactrim). I've also read a couple of abstracts about just Septra being using as a maintenance drug in European studies. Anyhow, I'll be speaking with the doctor about this today as I just don't think Imuran is going to work for my mom. Thanks for your reply, Pete!