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Thread: Rituxin - C19 and C20 and length of B cell suppresion

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    Quote Originally Posted by im so blessed View Post
    This is a great thread ! So from what these post say,being on higher doses of pred and having rituxan at the same time would probably be the easiest to then get an infection. Being that both B and T cells are depleted? One allowing you to get the virus, the other allowing it to settle into an infection? maybe thats too simple. I came on here today because this is exactly where im at and i was looking for this answer. I am on 20 mg of pred(coming down from 40) and i had rituxan 2 and 4 weeks ago. I have a virus that my children have. Stuffy nose n cough. So how long do i wait to see if my body fights it? or do i need to be right on it with dr?
    Watch for a temp - they don't always treat viruses with antibiotics but u have to be vigilant and let doc know if sx cont. Hydrate and eat healthy

    Lke Gab mentioned I believe you still have T cells. Not sure how long after doses of Rituxin before our B cells are depleted - I thought I read somewhere it could take a few months but I am not certain and with everything - we all respond a bit differently it seems.

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    Alysia, my message to you that you couldn't read was a link to this thread because I thought you would find it interesting . I see you found it anyway!
    Trust in the Lord with all your heart
    and lean not on your own understanding;
    in all your ways submit to him,
    and he will make your paths straight.
    Proverbs 3: 5-6

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    My Flow Cytometry report with B cell results just arrived in my MGH online acct. Here's a screen grab. Interestingly it says the % of T cells may increase when B cells decrease.

    Thought I'd share.

    edit: I took out blurry attachment -
    next post has clear attachment.
    Last edited by Gab122; 09-06-2016 at 01:47 PM. Reason: blurry image
    Trust in the Lord with all your heart
    and lean not on your own understanding;
    in all your ways submit to him,
    and he will make your paths straight.
    Proverbs 3: 5-6

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    That pic in the last post looked blurry despite picking "best quality" - this should look better...

    This should be clearer.
    Gab
    Last edited by Gab122; 09-06-2016 at 01:45 PM. Reason: clarification
    Trust in the Lord with all your heart
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    and he will make your paths straight.
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    Ok from what I just read online...
    The cd3, cd4, cd8 are all T Cells.
    The cd19, cd20 are B cells.
    Sound right?
    Trust in the Lord with all your heart
    and lean not on your own understanding;
    in all your ways submit to him,
    and he will make your paths straight.
    Proverbs 3: 5-6

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    Interesting Gab - my lab does not do the total breakdown like this. I am wondering how that data is used for the T cells?

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    Quote Originally Posted by Gab122 View Post
    Ok from what I just read online...
    The cd3, cd4, cd8 are all T Cells.
    The cd19, cd20 are B cells.
    Sound right?
    That's right. Check out: https://en.wikipedia.org/wiki/Cluste...ifferentiation

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    Quote Originally Posted by Middlesista View Post
    Interesting Gab - my lab does not do the total breakdown like this. I am wondering how that data is used for the T cells?
    Middlesista - Hmmm. I have no idea. This is my first time recv this info. I'll ask about it at my RA follow up on friday.

    Max, thanks for interesting link!

    I was looking at the report and wondered about this paragraph:

    "REFERENCE RANGE: Adult (age 18 and up).
    Reference: Clinical Immunology and Immunopathology 70,152, 1994. Immunology
    Today 13,215,1992."

    What does 7,0,152 and 13,215 reference I wonder. Is it my numbers or general population numbers. Or something else all together?
    Gab
    Trust in the Lord with all your heart
    and lean not on your own understanding;
    in all your ways submit to him,
    and he will make your paths straight.
    Proverbs 3: 5-6

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    OK. I'm ignorant on this. What is the C19 and C20 test? Blood test? Another name for something that appears in a CBC? Help please.
    Pete
    dx 1/11

    "Every day is a good day. Some are better than others." - unknown

    "Take your meds as directed and live your life as fully as you can." - Michael Chacey, MD

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    Quote Originally Posted by Pete View Post
    OK. I'm ignorant on this. What is the C19 and C20 test? Blood test? Another name for something that appears in a CBC? Help please.
    Hi Pete, From what I gather it's a test that checks your B cell levels. I don't think it's part of cbc or anything. Maybe it's used to determine if the immunosuppressant meds are working correctly or determine when you need your next round of Rituxan or other immunosuppressant.

    There are tests for the T cells, and other blood components as well. The cd3, cd4, cd8 are T cell indicators.

    If you are on something other than Rituxan there may be different cd tests they would run.

    Hope that helps!
    Trust in the Lord with all your heart
    and lean not on your own understanding;
    in all your ways submit to him,
    and he will make your paths straight.
    Proverbs 3: 5-6

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