SEVERE Nausea on Cytoxan

**Green Grass & High Tides** · 07-03-2015, 06:14 AM

Ive had gut involvement for 16 years with chronic nausea from wegs.

Cytoxan infusions are best foe me, pill wouldn't be my choice. The cytoxan, nausea is a different beast. Kytril and Ativan were suggested at the cancer center. They explained a complimentary mechanism when combined. But i take zofran and found through studies that alprazolam increases the effectiveness of zofran for nausea. So, i take the two together after infusions. I also go up on prednisone from 30mg to 60 mg which helps. Studies show dexamethasone has some value here too but i stick with pred and use synergistic hpa axis suppression to counteract the Paradoxical Effects of glucocorticoids on the immune system.

Confused about yet? Me too... but this has worked best for me.

Other things i use for weg gut based nausea is ginger tea and nutrition.

Hydroxyzine is something i tried last night instead of promethazine since it is milder and helps counteract the Paradoxical Effect of glucocorticoids on autoimmune disorders. Not sure how it will pan out yet... but its one that doesnt seem to trigger my wegs. I look for studies that show a synergistic HPA Axis suppression with all my meds. This has become a rule for me si ce the number one trigger of my wegs is stressors- internal or external. All stressors are processed through tbe HPA Axis which glucocorticoids like pred suppress. choosing meds that either dont mess w hpa or have synergistic suppression is required for me as of today.... subject to change...

Sent from my SM-G925V using Tapatalk