Hi Jayne,
I'm taking 15 mg/wk of mtx. I split the dose in half (breakfast and supper). I start feeling fatigued about six hours after the first pills, and it intensifies in the evening. The next day I'm a bit fatigued, but it's not debilitating. I'm back to normal the third day.
I would guess any adjustment in your dosage would be a function of your labs and your overall state of health. My rheumy told me that 15 mg/wk is the minimum effective dose. She wants me to continue as her research shows that people who discontinue mtx have a 40% probability of a flare within 12 months.
The fatigue I feel with mtx is my only side effect now. I'm down to 2 mg of pred. I feel very well otherwise.
Pete
dx 1/11
"Every day is a good day. Some are better than others." - unknown
"Take your meds as directed and live your life as fully as you can." - Michael Chacey, MD
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