I've never felt ill from mtx, but I do have some mild fatigue. The fatigue was more pronounced, but of about 12 hours less duration when I took the whole dose at once. My doctor said I could split the dose and take half in the morning and half later in the day. She also said to be sure to take the whole dose on the same day. Now, I take half the dose in the morning and the other half with the evening meal. If I'm not engaged in an activity, I start to feel a little tired in the early afternoon, and the feeling continues until the evening of the next day.
I also take 1 mg/day of folic acid to combat the potential hair loss that mtx can cause. So far, that's working ok.
Pete
dx 1/11
"Every day is a good day. Some are better than others." - unknown
"Take your meds as directed and live your life as fully as you can." - Michael Chacey, MD
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