IVIG treatment - please help

[Alysia]

Hi. As some of you know I am with Phil in the ICU. I need all the info you can give about it. Thanks.

[Alysia]

Thanks again Kirk for the priceless info that you posted here http://www.wegeners-granulomatosis.c...tinued-15.html I just resd it again.

[Alysia]

I need info about how many times anyone here got it, in what intervals of time, what doze, etc. understood that there are different protocols if its for active wg or to help fight infections ? What do you know about it ? What should be the Igg in order to give it ? Thanks.

[mrtmeo]

I know this is way too late, but thought it might be helpful for others.
This nasty disease is the biggest learning experience in my life.

Intravenous immunoglobulins (IVIG)
ANCAs can induce cytokine-primed neutrophils undergo degranulation and respiratory bursts during which they release toxic oxygen species and lytic enzymes.
Anti-idiotype antibodies with inhibitory effects on ANCA in vitro have been found in a pooled human gamma globulin preparation.

Evidence showed that IVIG acts in different phases of the immune response including neutralization of circulating pathogenic antibodies, Fc receptor modulation, blockade or suppression of antibody-dependent cell
toxicity, natural killer cell function, auto antibodyproduction and complement activation, and acceleration
of neutrophil apoptosis.

Beneficial effect of high-dose intravenous immunoglobulin in ANCA–associated vasculitis has been approved by different studies. Ito et al evaluated IVIG monotherapy (400 mg/kg/day for 5 days)in AAV patients.
Their study showed that IVIG decreased the leukocyte count, C-reactive protein level, Birmingham Vasculitis Activity Score and improved the systemic symptoms
Other studies suggested that IVIG induces remission in 40–82% of patients

IVIG
appears to have an important place in the management of ANCA-RPGN, but it's indications have not been determined. Because IVIG is an expensive drug additional studies on its cost-effectiveness and rational introduction into clinic al practice are needed.

http://cdn.intechopen.com/pdfs-wm/22836.pdf

[mrtmeo]

I found this that IV Ig can cause renal failure here

http://jasn.asnjournals.org/content/13/7/1953.full