I agree with Jack about getting off the cyclo, Germaine. Staying on it longer than 9 months is not very typical. By that point, the Wegs should be under control enough to change to a less toxic immunosuppressant. I've never heard of decreasing the cyclo. Usually you just transition onto the next drug (or no drug at all, if you're definitely well into remission). Do you have a Wegs specialist? An internist does not have nearly the training to treat Wegs.