Research! The Assessment of Prednisone in Remission Trial (TAPIR)

[lag713]

www.TAPIRTrial.org
https://www.youtube.com/watch?v=WQN-fJH8oswz

What we are studying:

The TAPIR Trial is helping us learn more about how to manage the care of people affected by granulomatosis with polyangiitis (Wegener's, GPA) who are in remission.

We would like to learn more about whether patients with GPA are better off being maintained on low-dose prednisone or attempting to come off prednisone altogether when they are in remission.

Who can participate in TAPIR?

You may be eligible to participate if: You have been diagnosed with granulomatosis with polyangiitis (GPA, also known as Wegener's granulomatosis) You have needed to take 20 mg or more of prednisone each day at some point in the last 12 months You are currently taking prednisone (Please note that you may be on other medications for your GPA besides prednisone and still participate in the TAPIR trial) You are at least 18 years of age Your physician is based in the US or you can travel to a VCRC Clinical Center *Other conditions may apply

How to join the TAPIR trial:

There are 2 ways you can join the TAPIR trial.

*JOIN TAPIR ONLINE*

You do not have to live near a clinical center to join! You can join online and continue to see your own doctor. Visit www.TAPIRTrial.org

[lag713]

I'm ineligible but I thought there might be some interest from the forum.

[renidrag]

I am too. Off prednisone for way too long.'
Dale

[rebekah]

I got an email for it today and wanted to take part in it, but after reading more about it I'm not eligible either. I'm taking 35mg of pred, a lot more than 6-10mg. I'll definitely keep an eye out for future emails about studies that are going on.

[Alysia]

just saw this one on fb. thanks Jana

[drz]

I'm ineligible but I thought there might be some interest from the forum.

I wonder if this isn't also being addressed some what in the longitudinal study on treating GPA. I know they have a list of my meds and do lab work every time to assess things along with several clinical questionnaires. I am continuing on a low maintenance dose of 5 mg and 175 mg AZA too because it is thought it might help reduce risk of flares or relapse.

[Debbie C]

It will be interesting what they conclude.Since all the drs. say you need to be on some sort of maintence drug

[MCC]

It will be interesting what they conclude.Since all the drs. say you need to be on some sort of maintence drug

They don't all say that. Sure there are quite a few who are entirely off meds.

[drz]

They don't all say that. Sure there are quite a few who are entirely off meds.

One study indicated 20% can get drug free and stay in remission for at least three years. More research will help clarify who is most likely to do this and what approach is most effective to do so. Right now it is a try taper off and see what happens method.

[Alysia]

Right now it is a try taper off and see what happens method.

I don't think I will ever dare to try taper pred again, after last time, when I tried to reduce from 5mg to 4 mg and got the worse headaches in my life