Methotrexate and Omeprazole

[Kami]

Hello! I just found this on the internet and thought I would share. I dont' understand much of it but the last sentence makes sense to me! Any thoughts?
I don't think I will be taking Omeprazole until I can talk to my doctor about it. I was taking it because sometimes I wake up at night with acid reflux.


Abstract

Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.

Impact of omeprazole on the plasm... [Cancer Chemother Pharmacol. 1993] - PubMed - NCBI

[Kami]

Here is one on Prilosec which I think is similar to Omeprazole. Screamin' meanie you aren't taking these together are you? Just thinking of your side effects.

Methotrexate/Proton Pump Inhibitors
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Proton pump inhibitors may decrease the ability of your kidneys to remove methotrexate from your body.
What might happen:
The amount of methotrexate in your body may increase, which may cause more serious, potentially life threatening side effects.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your doctor may want to monitor the amount of methotrexate in your blood, change the dose of your methotrexate, or change your acid medicine. Let your doctor know right away if you develop nausea, stomach pain, yellowing of the eyes or skin, dark urine, fever, fatigue, a persistent sore throat, easy bruising or bleeding, black stools, a change in the amount of urine you pass, skin rash, breathing problems, dry cough, diarrhea, or mouth sores while taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

webiste:
Interactions between Prilosec Oral and METHOTREXATE

[Dryhill]

Thank you for that info Kami. I have been taking Omeprazole because I am on Ctx, but as I am being weaned off Ctx I am taking Methotrexate at the same time.I am at vthe hospital tomorrow for a Ctx infusion so I will query taking Omeprazole.

[pberggren1]

Omeprazole is to protect the stomach from pred.

[Al]

Omeprazole is to protect the stomach from pred.

Omeprazole was prescribed to me despite my CTX being in IV form. I complained to Drac, on the grounds that the ulcer research was inconclusive, so there was no reason to further screw around with body chemistry. He actually agreed....

Al

[Dryhill]

When I was at the hospital today I showed the article to one of the dopctors and she said that was one of the things that they were checking for when I have my fortnightly blood test. So if you are concerned about the effects of Omeprazole and Methotrexate ask for a regular blood test to check on the build up of Methotrexate.