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Methotrexate and Omeprazole
Hello! I just found this on the internet and thought I would share. I dont' understand much of it but the last sentence makes sense to me! Any thoughts?
I don't think I will be taking Omeprazole until I can talk to my doctor about it. I was taking it because sometimes I wake up at night with acid reflux.
Abstract
Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.
Impact of omeprazole on the plasm... [Cancer Chemother Pharmacol. 1993] - PubMed - NCBI
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