Hello! I just found this on the internet and thought I would share. I dont' understand much of it but the last sentence makes sense to me! Any thoughts?
I don't think I will be taking Omeprazole until I can talk to my doctor about it. I was taking it because sometimes I wake up at night with acid reflux.


Abstract

Omeprazole inhibits the gastric hydrogen pump and is an effective treatment for peptic ulcers. Methotrexate is a chemotherapeutic agent that inhibits dihydrofolate reductase and is eliminated by a hydrogen-ion-dependent mechanism in the kidney. We present evidence that omeprazole inhibits methotrexate clearance and may result in potentially toxic methotrexate levels.

Impact of omeprazole on the plasm... [Cancer Chemother Pharmacol. 1993] - PubMed - NCBI