Multiple Family Members w/ Weg's

[Sangye]

David, you CANNOT get Wegs from another person. Inheriting a gene for it is entirely different, and even that is just a theory with paltry evidence to support it.

[mishb]

No AI's in my family (and there 11 siblings altogether) apart from me and I managed to get a nice little package of them. Maybe I got everyone's worth.

As for it being environmental, Myself, my eldest daughter and my husband all work together as well as lived together (up until a year ago when my daughter moved into her friends house) and they both are fine, as well as my youngest daughter. Same food, same water, same home and working environment.

No clues here, I'm afraid.

[Trudy]

A thought to ponder….I was diagnosed with Lupus (SLE) in 1998. I have been positive in Anti-Sm antibodies which are strongly selective for Lupus plus Anti-Ro antibodies which usually indicate Sjogen’s syndrome. The Anti-Ro is known to be able to cross the placenta. I have nine adult children. Two of which have my same blood type (A neg). Of these two one has been battling Lupus for 4 years and the other has many of the symptoms but has never been tested. My other kids are fine. The past two years I have also been battling vasculitis. I am positive in both ANCA-MPO and ANCA-PR3; have a lung nodule; sinus, mastoid, and brain stem inflammation; eye pressure etc. So…….could the susceptibility to autoimmune disease in some cases just be passed through the placenta rather than a specific inherited gene?
The Lupus forum I visit has lots of members with more than one autoimmune disease and a number with Lupus and some type of vasculitis. Many have siblings or parents with autoimmune disorders too.

[Rini]

A thought to ponder….I was diagnosed with Lupus (SLE) in 1998. I have been positive in Anti-Sm antibodies which are strongly selective for Lupus plus Anti-Ro antibodies which usually indicate Sjogen’s syndrome. The Anti-Ro is known to be able to cross the placenta. I have nine adult children. Two of which have my same blood type (A neg). Of these two one has been battling Lupus for 4 years and the other has many of the symptoms but has never been tested. My other kids are fine. The past two years I have also been battling vasculitis. I am positive in both ANCA-MPO and ANCA-PR3; have a lung nodule; sinus, mastoid, and brain stem inflammation; eye pressure etc. So…….could the susceptibility to autoimmune disease in some cases just be passed through the placenta rather than a specific inherited gene?
The Lupus forum I visit has lots of members with more than one autoimmune disease and a number with Lupus and some type of vasculitis. Many have siblings or parents with autoimmune disorders too.

the blood type thing is very interesting

[Rini]

what would happen to someone if they got my blood now? I can't imagine it would b good.

[Sangye]

Trudy, that's very interesting about the Anti-Ro antibodies being able to cross the placenta. I'd loved to hear what the researchers have to say about all that.

Rini, you should not donate blood. Not that anyone is going to "catch" Wegs, it's just not a good idea to share all the drugs you've had.

[delorisdoe]

rini,,,in canada if you are on these meds and donate blood you get a letter in the mail that says "thank you for your support of the red cross but at this time we are unable to use your blood due to the following ..." lol. it is a very polite letter

[Sangye]

They don't eliminate you as a donor before you donate? If that's the case, considering all the wasted supplies and volunteer effort, it's better not to do it in the first place.

[delorisdoe]

Actually I have not given blood myself but yes they do ask a series of questions regarding tretments you may be on. My uncle receives this letter every few years or so when his iron is low.

[RCOSSIO]

Yes...it was my Uncle and possibly my grandfather (his father) as well back in the 60's. My first cousin (same lineage) also has an AI disorder. Its the family tree...yet we still haven't figured out how to win the Powerball Lotto.

GO FIGURE