Originally Posted by
Sangye
No one really knows exactly how rtx works to control Wegs. Yes, we know that rtx targets the CD20 receptor on B cells and kills the B cell, but we don't know how that controls Wegs. In fact, they don't fully understand the mechanism of Wegs itself! They used to think T cells were the issue with Wegs, not B cells.
He said it all makes for a good story-- bad B cells produce antibodies that attack the blood vessels, rtx kills those B cells and the Wegs gets under control-- but there are huge chunks missing from the story. So they are really still in the dark about Wegs, much less rtx. I thought this was fascinating.
Wow, this is all very interesting for me as someone about to start out on RTX.
Solumedrol - Why dont you like it Sangye?? And this wasn't mentioned at my last visit to Addenbrooke's maybe they'll talk about it nearer the infusion date. And they also said that it was very rare for people to have a reaction to RTX...hmmm.
Why dont they base the 2 infusions on weight but they do with the 4? This concerns me as a larger person. It was mentioned that they would look to getting my weight down after i come off MTX and Pred. As for me i cant wait to get off the stinking Pred.
Thanks for asking Dr Seo Sangye, what a guy.
"I believe that I have seen a negative attitude kill people, but I don't think that a positive one will cure you. However, I know that it Helps". Jack
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