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Thread: tissue samples

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    Default tissue samples

    Ok have a question for all you oldies with WG limited....Can you get a positive tissue sample if the dog is sleeping?
    Can you get a negative result if alot of inflammation is going on in the areas they pull from for other reasons beside WG?
    IS THE TISSUE EFFECTED WITH WG ALWAYS EFFECTIVE???????
    And last but not least do you have to have a positive tissue to have WG?

    I know we have discussed this in the forum but i keep getting conflicting data and one of the non WG docs at Mayo realy rattled my cage so to speak.....
    Thanks
    Lisa Marie
    Want to see a miracle? Plant a word of love heartdeep in a person's life. Nuture it with a smile and a prayer and watch what happens...Never underestimate the power of the seed!

    My mojo for today.....gonna be johnny apple seed and just keep planting
    Lisa Marie
    The happiness of people is not necessarily to have the best of everything...but make the most of what you have!!

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    I've never had a tissue sample taken. As I understood it the diagnosis can be made with postive ANCA and stenosis alone as WG is one of the very few illnesses that cause stenosis of the trachea.
    ~ Bob

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    What if you have negative ANAC and no tisssue samples but everything else...sinus ...joint pain...funcky swelling of mandible...raising CRP.....I thought both could be negatice and you can have WG with Tracheal stenosis...especially when they rule out reflux as a causitive agent...i had silent reflux but vocal cords clear...and am now on nexium and zantac and still have clear vocal cords...ughhh....i just get so confused when a doc says something..even if he is not the specialist
    Want to see a miracle? Plant a word of love heartdeep in a person's life. Nuture it with a smile and a prayer and watch what happens...Never underestimate the power of the seed!

    My mojo for today.....gonna be johnny apple seed and just keep planting
    Lisa Marie
    The happiness of people is not necessarily to have the best of everything...but make the most of what you have!!

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    Honestly, I'm probably not qualified to say. I believe there are folks on the forum that have WG and have never had a single positive test. Don't doubt the diagnosis if it fits...I've been down that self doubt trail a bit myself.

    As a side note I seem to remember my ENT saying that samples from the trachea are rarely affective, and that they didn't bother with me because I had the other markers. If you have the diagnosis I'm sure they based it on the overall picture.
    ~ Bob

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    I think Bob is correct, most doctors will give a diagnosis based on the overall picture. I had two tissue samples taken, one from my lung and one from my nose, and both came back inconclusive...which, to my understanding, is par for the course, it is rare to get a 100% confirmation from tissue samples.
    I'm unsure about you not having any ANCA levels, I thought that was a big factor in diagnosing WG, but I'm not sure that it is necessary for diagnosis...hopefully someone else can chime in with more info about that.
    I don't think effected tissue will necessarily always be effected, it can heal and become healthy tissue again.
    Nicole

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    You can have a (-) biopsy and (-) ANCA and still have Wegs, especially when the biopsy is from the upper respiratory area-- famously inconclusive.

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    thanks.....o hate this self doubt crap it really send u on a roller coaster all of it s own
    Want to see a miracle? Plant a word of love heartdeep in a person's life. Nuture it with a smile and a prayer and watch what happens...Never underestimate the power of the seed!

    My mojo for today.....gonna be johnny apple seed and just keep planting
    Lisa Marie
    The happiness of people is not necessarily to have the best of everything...but make the most of what you have!!

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    I am flaring now and have neg ANCA and neg biopsy.

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    thanks Phil...it s nice to know I am not the only one
    Want to see a miracle? Plant a word of love heartdeep in a person's life. Nuture it with a smile and a prayer and watch what happens...Never underestimate the power of the seed!

    My mojo for today.....gonna be johnny apple seed and just keep planting
    Lisa Marie
    The happiness of people is not necessarily to have the best of everything...but make the most of what you have!!

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    Definitely not uncommon Lisa -- I was biopsied at the time of my stenosis surgery, and all came back inconclusive. I was + ANCA and high P3 at the time.

    Stenosis and saddle nose are really easy diagnostic markers -- like Bob says very few diseases cause it, and WG is the main one.

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