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    Default Methodrexate

    I have been on Pred for about 10 months and am now down to 13mg per day - but my WG specialist here in France has changed me to Methodrexate (10mg rising to 15mg pere week) starting this week (with an overlap Pred period.)

    Can ayone help me with my apprehensions, which are mainly to do with the possible side effects - nausea, vomiting, hair loss etc - thanks, Simon

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    Hey simon..

    Ive been on methotrexate since June 2010. Started on 15mg and now on a constant 20mg per week. I think I have been fortunate with it so far... I take mine on a Friday morning and do experiance increased tiredness on the following saturday especially. Occasionally I will feel a little nausea but never been a problem. Apart from that I have suffered a little hair loss - nothing that is noticable though. Just noticed from brushing and in the shower that more hair comes out that normal.

    I did have one abnormal blood test result last August when I originally increased it to 20mg per week. I had increased liver enzymes and had to come off it for a few weeks to normalise the liver but apart from that nothing major. Hope everything goes well with you first dose.

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    Been on Mtx for over a year now on larger doses (both oral then injection)than you with no known side effects. . Some do have problems - like many things in life, whats is good for one may not be so good for others - hope you are in the former group.
    Behind every great man is a woman rolling her eyes.
    Jim Carrey



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    Thanks for that - good to hear of your lack of side effects - Simon

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    Hi Simon, I was only briefly on mtx injections but didn't notice any side effects. (I was in pretty terrible shape already, so that data might not count!) I have noticed a trend on here-- people taking the injections say they experience fewer side effects versus the oral.

    It's always scary starting a new drug.

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    thanks for this info, Simon

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    Thanks for letting me know experiences - a problem shared and all that !!!!

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    Hi,

    Just to add to the collection of replies, I've been on Methotrexate for 2 years and am still on it along with 10mg of Pred. I take 25mg/week via injection, have no side affects in that I feel fine - of course, I'm not the same as I used to be for energy levels - probably the Methotrexate working on the immune system has something to do with it. Hair loss - about one third of it during chemo drug, but it came back once on Mtx but it's still not quite as full which is expected if you understand how Mtx works. I did find however that I became anemic - again just how mtx works - so I do take an iron supplement every day. Other than that, I don't feel any different on the day I take it to the other 6 days I don't - definitely an eaiser drug for me to take.

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    I started on mtx last Mar10 when I was diagnosed. I was on 15mg once a week up until Jan11. At 15mg, I had no noticable side affects. At least, none that I couldn't readily blame on one of the other half dozen drugs I was taking.

    However, about a month ago, I started to taper up by one pill per week until I hit 10 (25mg). I took my first 25mg dose last Thur morning. I was fine all day, but mid-aft, I thought I was halfway into the grave -- stomach cramps, nausea, headache, dizzy, and dead tired. I beleive the mtx was the culprit. I ate nothing and went to bed.

    I am much better today, but I do notice that my muscles and my joints ache like the dickens. Particularly my elbows, knees and the muscles leading up to them. They all hurt. I literally have to roll out of bed. Once I get some tylenol and tramadol into me, I get along ok, but the underlying pain is still there. Is it the mtx or the wg? I guess if I have the same experience this Thur, then I'll have a good idea it's the mtx.

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    hi am new here i am on pred been on it 4 13 months now was on 60 now down to 10mg a day.was put on methotrexate 5 months i am on 10mg a w eek thay will have to put it soon.i have not had eny side effects you will not have hair loss only think i can say i may get a bit nausea but it nothing.please dont worry am on pred and meth dont no when i will b of the pred but the meth will go up when i come of them may b 3 months time.hop this has help u . pauline

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