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Thread: Anybody taking Bactrim + Methotrexate?

  1. #11
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    Quote Originally Posted by Jack View Post
    There was at least one trial run on Bactrim to prevent relapse which lasted for two years. Duing this time 82% of the Bactrim group remained in remission against 60 % of the placebo group. The conclusion to this report speculates that infections trigger relapse and this is why Bactrim helps.
    I recall reading that in a couple of places, too. That's one of the reasons I wanted to stay on it.

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    This makes me think of the controversy about keeping Weggies on maintenance drugs "just in case." Staying on an antibiotic long-term also has risks-- creating antibiotic-resistant bacteria, developing an allergy to it, chronic disruption of normal gut flora, etc....

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    I'm with you on this one Sangye. And so is my doc too.

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    Plus I'm not allowed to get pregnant while on it. Since I am a 52 year old male, I find this HIGHLY prejudicial!

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    By the way my doctor says the combination of MTX and Pred are making me paranoid, but I just think he's just saying that because he's out to get me.

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    I don't want anyone to get the wrong idea about my last comment. Some Weggies have demonstrated that they need to stay on Bactrim to avoid infections and/or Wegs flares. In that case, the benefit outweighs the risk. My comment was directed at doctors who put Weggies on Bactrim indefinitely, without even seeing how they do without it.

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    I'd have to dig this up, but there was a study in one of the medical journals that indicated a persistent sinus infection could lead to recurrence and flareup. If so, then Bactrim would be a good idea to prevent or mitigate a sinus infection. This could be one of the reasons why Bactrim may mitigate recurrence. IMHO.

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    Trimethoprim-sulfamethoxazole (co-trimoxazole) for... [N Engl J Med. 1996] - PubMed result

    MMS: Error

    Some other interesting stuff here - co-trimoxazole wegener's - PubMed result

    Unfortunately most of these are just abstracts.
    Note: in the UK Bactrim is called Co-Trimoxazole.
    Last edited by Jack; 12-16-2010 at 09:16 PM.
    Jack

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    Bactrim is also called Septra in the US. Apparently we can't handle drug names over 2 syllables.

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    It's always so hard to say, right, because the samples are always so tiny (only 36 patients in one of the abstracts I opened).

    Again, I think it's up to every patient to evaluate their individual case with their docs, but, I met many people who went on pred and immediately went on fosamex (with no evidence of bone loss) at the Symposium, I also met many patients who went on were on imuran or mtx and still on bactrim left over from the ctx days (when it shows a clearly clinically significant benefit in preventing a certain type of pneumonia). Doctors sometimes think that more is better as it is keeping away this dreaded disease; I don't think that true WG docs are nearly as nervous about treating the flare as it arises.

    I don't think that "let's never have her flare again in her whole life" factors strongly into my doctor's treatment decisions about my case.

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