Been on it since March and have had no side effects at all -- wouldn't even know I was taking it if I didn't pop the pills myself. I'm on 17.5 mg/week.

Although I've seen many on here struggle with side effects, one of the reasons that it's so popular in my doc's practice (particularly for RA patients) is the lack of prominent side effects, even at the highest dose he prescribes (32.5 mg), and people's ability to stay on it for years. You just can't drink much alcohol (some docs say none at all).