I was on mtx for about 9 months. Initially 20mg per week and this was upped to 25mg after about 6 months when some wg symptoms were creeping up. Folic acid was taken on day 3 after the mtx.
I hated the tablets with a passion - generally felt down the following day (Sunday) after taking it, but was usually good for work by the Monday morning! It wasn't until I flared about 6 weeks ago, stopping the mtx and starting the cyclophosphamide again, that I realise how bad I felt - not sure how much of it was mtx and how much was wg. Certainly the initial upping of the pred 10 fold and starting the cyclo I feel so much better again. I did react a bit to the second cyclo infusion but I can tolerate a couple of bad days every 3 weeks better than bad days every week!
I cracked a rib back in June / July, leraning over the side of my dinghy! It has never been teh same since!
I was going to have a colonoscopy the day after I flared as my bloods were showing bad signs - this was cancelled when I flared and, since coming off the mtx, those readings have started to recover, to the point where they don't feel it is now necessary!
I believe I am going to go onto azathioprine after this cyclo round.
There is an interesting article about mtx in the following document link -
ACR/ARHP Wednesday/Thursday Daily News 2010
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