Methotrexate Side Effects
I have been diagnosed with WG for 3 years now. Currently I am on 5 mg Prednisone daily and 25 mg MTX weekly. I have tried both MTX tablets and injections but both make me feel really bad for 1-2 days after taking. Headache, nausea, abdominal cramping and general "fog". Any suggestions out there? Thanks.
Re: Methotrexate Side Effects
I realise Im replying to an old post but ...Do not take folic acid for at least 24 hours after taking your Methotrexate. It will interfere with its action. Then 5mg daily for 2 days.
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Re: Methotrexate Side Effects
Hi, I have been taking MTX (20mg per week) since 2013 and quite soon my skin was getting yellow and liver function tests not so great. So I needed to find a solution, it was berberine, yellow stuff with bitter taste.
According to several rat studies(here's one: https://www.sciencedirect.com/scienc...5333221733295X ), berberine protects liver from cytotoxin. With random-regular use of berberine I have very minimal MTX-nausea and my blood values are all just fine.
Ok, I have to admit that I dont know if berberine is neutralizing the very effect of MTX. In some cancer treatments it's ok to take berberine and in some it's not, depending the cytotoxin type used.
What comes to folic acid, it seems that usage recommendation vary quite a lot from place to place. I live in a Nordic country and my University hospital prescription says to take folid acid 3-5 hours after the MTX.
One warning relating to berberine, it's very safe product, but if you have diabates-2 medication, you will most likely have to adjust your medication as berberine also acts like an metformin and lowers blood sugar values.
Re: Methotrexate Side Effects
Hi Trionic
All of the studies that I have read advise not to takefolic acid (folate)on the same day as MTX
Others say not to take it within 24 hours either side of taking MTX, and again others say, not to take within 12 hours either side of MTX
Everyone has different ideas, but I have never heard of 3-5 hours after :unsure:
If your liver is so affected, can your specialists not put you on to a different medication and drop MTX altogether?