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Middlesista
04-19-2022, 03:55 AM
Hello folks - I have not been able to find this information so was hoping a fellow GPA person might be able to help. I had Evusheld in March. I have been one of those w/GPA that has had Rituxin every 6 months. Does Rituxin deplete the antibodies that Evusheld provides you? I had 3 vaccines plus booster and had no response. Thanks!
Pete
04-19-2022, 03:00 PM
Middlesista

I asked Dr Villa Forte at Cleveland Clinic the same question. Short answer is that evusheld does not deplete rtx antibodies, but complements them.
John S
04-19-2022, 09:56 PM
If someone could be tested for antibodies, it wouldn’t hurt.
Middlesista
04-19-2022, 10:16 PM
Thanks Pete!
Middlesista
04-19-2022, 10:18 PM
Has anyone been tested for antibodies after the evusheld?
Middlesista
04-20-2022, 03:25 AM
Are there tests for Evusheld antibodies?
gunnyl
05-08-2022, 05:44 AM
Rituximab doesn't deplete your existing antibodies, it depletes your B cells which are needed to develop antibodies.
According to my rheumy they don't interact with each other in any way. I am getting Evusheld the same day and in conjunction with my infusion.


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drz
05-10-2022, 10:43 AM
Rituximab doesn't deplete your existing antibodies, it depletes your B cells which are needed to develop antibodies.
According to my rheumy they don't interact with each other in any way. I am getting Evusheld the same day and in conjunction with my infusion.


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Thanks for this info. It is reassuring and helpful in dealing with these complex questions about our treatment and management of GPA.
gunnyl
06-28-2022, 06:38 PM
Update
I got the Evusheld injections in conjunction with my infusion a couple weeks ago. It was a really rough infusion cycle and took me longer than usual to recover.
A week and a half later my son tested positive for covid and was symptomatic. I spent the better part of a day in a car with him two days before he presented with symptoms.
I never presented with symptoms and never tested positive.


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Meredith
08-17-2022, 04:52 AM
I had Evusheld in April - tested for the antibodies in June and I had them. I am in remission with Wegeners right now, have been for 2 years so no Rituxan right now. I have CLL now also to deal with. Had Covid in Jan. with long symptoms which lasted approx. 2 months (long-term fever). Get Evusheld again I believe in October.