Qnasl: Suffering with muffled ears? Rhinitis? Dump the Prednisone first …

[Bing505z]

….. then get your ENT to prescribe Qnasl for you. Last year I had the muffled ears and the buildup in the nose and sinuses, and it took several months for it to go away after my Rituxan round last February.I haven’t had any problems until a few weeks ago. I started having muffled hearing, a stiff nose with lots of huge buildup again, my apologies, so I ran to the ENT first.I was like do I need Pred etc.and he said nope and prescribed Qnasl.Qnasl is a spray for your nose. It contains beclomethasone, a corticosteroid. It prevents the release of substances in the body that cause inflammation. It also known to help with Eustachiantube dysfunction - muffled hearing etc.
So it takes like a week or so for it to kick in, for me I did 2 sprays in each nostril every day for 7 days, and everything went back to normal. No muffled hearing, no nasal build up. I only need to do my nasal rinse maybe once a week now. It was like getting new ears and a nose after 7 days. If you suffer…give it a try and ask your ENT to write a RX for ya.

[Green Grass & High Tides]

Thanks Bing! Sounds like a better option than prednisone. Glad you're feeling better. I looked at the Glucocorticoid listed Beclometasone dipropionate / or beclomethasone dipropionate and found this HPA Axis warning listed:
Hypothalamic-Pituitary-Adrenal (HPA) Axis SuppressionAvoid higher than recommended dosages of the drug, since suppression of HPA function may occur.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149) If higher than recommended dosages are used, carefully consider the relative risks of adrenal suppression and potential therapeutic benefits.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149) Recommended dosages of orally inhaled drug provide less than normal physiologic amounts of glucocorticoid systemically and do not provide mineralocorticoid activity.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149)Orally inhaled drug will not compensate for insufficient endogenous cortisol production caused by previous systemic corticosteroid therapy.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149)

http://www.drugs.com/monograph/beclomethasone-dipropionate.html
I've used Flonase (fluticasone propionate) and other intranasal spray steroids (http://www.ncbi.nlm.nih.gov/pubmed/26132312) since about 2000 for wegeners. This HPA Axis stuff eventually became a major factor in my wegeners recovery and I now believe it to play a central role in remission maintenance. I'm particularly impressed that they included the statement "and do not provide mineralocorticoid activity." since this(GC) (MR) imbalance appears to be significant in disrupting my HPA Axis and triggering the auto immune disorder. I can get temporary relief from the steroid while at the same time it aggravates the wegeners.

its disruption can lead to predisposition to or aggravation of autoimmune diseases. http://www.ncbi.nlm.nih.gov/pubmed/11155801 (http://www.ncbi.nlm.nih.gov/pubmed/11155801)


A recent study was done comparing Flonase, Qnasl and Nasonex (http://www.ncbi.nlm.nih.gov/pubmed/?term=qnasl). They found that the Qnasl stayed in the sinus cavity better than the other two.

[Bing505z]

Thanks Bing! Sounds like a better option than prednisone. Glad you're feeling better. I looked at the Glucocorticoid listed Beclometasone dipropionate / or beclomethasone dipropionate and found this HPA Axis warning listed:
Hypothalamic-Pituitary-Adrenal (HPA) Axis Suppression

Avoid higher than recommended dosages of the drug, since suppression of HPA function may occur.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149) If higher than recommended dosages are used, carefully consider the relative risks of adrenal suppression and potential therapeutic benefits.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149) Recommended dosages of orally inhaled drug provide less than normal physiologic amounts of glucocorticoid systemically and do not provide mineralocorticoid activity.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149)Orally inhaled drug will not compensate for insufficient endogenous cortisol production caused by previous systemic corticosteroid therapy.149 (http://www.drugs.com/monograph/beclomethasone-dipropionate.html#r149)

http://www.drugs.com/monograph/beclomethasone-dipropionate.html
I've used Flonase (fluticasone propionate) and other intranasal spray steroids (http://www.ncbi.nlm.nih.gov/pubmed/26132312) since about 2000 for wegeners. This HPA Axis stuff eventually became a major factor in my wegeners recovery and I now believe it to play a central role in remission maintenance. I'm particularly impressed that they included the statement "and do not provide mineralocorticoid activity." since this(GC) (MR) imbalance appears to be significant in disrupting my HPA Axis and triggering the auto immune disorder. I can get temporary relief from the steroid while at the same time it aggravates the wegeners.

its disruption can lead to predisposition to or aggravation of autoimmune diseases. The cytokine-HPA axis circuit contributes to prevent or moderate autoimmune processes. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/11155801)


A recent study was done comparing Flonase, Qnasl and Nasonex (http://www.ncbi.nlm.nih.gov/pubmed/?term=qnasl). They found that the Qnasl stayed in the sinus cavity better than the other two.



Thanks for that info also. I didn't really feel bad, but it was more of an annoyance, and I was amazed how fast it worked and my muffled hearing and ear popping went away. I wish I had this a year ago.:thumbsup: