LisaT
05-16-2014, 08:45 AM
Sorry if this is already on here somewhere. It's a year old but good comparison of the different meds and in what situations they're used. And a few towards the end of the article that sound as though they're still experimental but good if others fail. This is the summary and I'll paste the link to the PDF below:
The treatment of AAV is directed at achieving disease control to prevent morbidity and mortality, while minimizing treatment toxicity. Corticosteroid use remains critical in rapidly achieving disease activity suppression, whereas cyclophosphamide and rituximab regimens should be reserved for induction of severe generalized disease, and plasma exchange for severe renal disease. In less severe cases of systemic disease methotrexate is suitable for remission induction. Maintenance of remission is achieved preferably with azathioprine or methotrexate, with leflunomide, mycophenolate mofetil and cyclophosphamide remaining as options. Finally, new discoveries and research will certify the role of alternative agents, such as monoclonal anti-tumor necrosis factor therapy, IVIg, DSG, ATG and CAMPATH-1, in refractory disease.
http://cdn.intechopen.com/pdfs-wm/42992.pdf
The treatment of AAV is directed at achieving disease control to prevent morbidity and mortality, while minimizing treatment toxicity. Corticosteroid use remains critical in rapidly achieving disease activity suppression, whereas cyclophosphamide and rituximab regimens should be reserved for induction of severe generalized disease, and plasma exchange for severe renal disease. In less severe cases of systemic disease methotrexate is suitable for remission induction. Maintenance of remission is achieved preferably with azathioprine or methotrexate, with leflunomide, mycophenolate mofetil and cyclophosphamide remaining as options. Finally, new discoveries and research will certify the role of alternative agents, such as monoclonal anti-tumor necrosis factor therapy, IVIg, DSG, ATG and CAMPATH-1, in refractory disease.
http://cdn.intechopen.com/pdfs-wm/42992.pdf