is weggies genetic???

[nessa]

jus wondering if wg is genetic im so scared that my four year old will develop it. she has had a few nose bleeds and its alarming to me bcuz that was my first sign of weggies. i talked to her doc and he referring us to a pediatric rhemotologist to get blood work done to see if she might i have it fingerz crossed that she doesnt i just dont think i can handle it if she does i know how horrible this illness can be and i do not want her to go threw this...

[Dryhill]

I have been assured by my doctor that WG is not genetic, he did go on to say that there is a very, very slight increased risk. Some studies by the UK's NHS shows that there is a 1:250,000 chance of getting WG and for children of a sufferer a 2:250,000 chance of contracting the disease.

My daughters are 29 and 32 so I have told them of the slight risk but have made sure they know about all the various symptoms so they can go to a doctor earlier rather than risk WG not being diagnosed. Having said all that it is a good idea to get your daughter checked out, there is still plenty more to learn about this disease (like why is it virtually unheard of in Japan and why are all immune diseases on the increase?).

[maria garcia]

I believe Auto Immune disorders are. My mother in law had scleroderma (AI) and now my daughter has Wegners. Just my idea nothing proven. My Rheumy said yes. But everything I have read does not give a concrete answer.

[vdub]

Everything I've read about GPA is that it is not genetic.

[Al]

Everything I've read about GPA is that it is not genetic.

Yes and no. There is, as Dryhill says, a slightly increased risk with family association, but it is difficult to distinguish between family correlations and actual genetic causes. At any rate, genetics do come into play, but at the level of day-to-day gene expression (which genes are turned on and off on an hour-hour basis), rather than the content of the DNA molecule. There are many factors that drive gene expression. This warrants a long discussion, but...another time. The easy answer is, though this question is complicated, there is no clear genetic component.

Al

[jola57]

There are test being done to determine if it's genetic. Nose bleeds are normal in children and may be due to dryness. I hope the test will show all is just fine and your little girl is as healthy as can be.

[Rose]

I try not to think that this disease might be genetic but find myself worrying when either of my children complain of something. A few years ago my daughter was getting one sinus infection after another and I worried. That time was exam stress which was making her more susceptible to illness. Once that was over she has been fine. Recently she has been complaining of aches in her hands. She thinks it is from a lot of typing...sure it probably is but still I am concerned. I do not say anything to her or my son but it is always at the back of my mind. I tell myself that at least should WG show itself in my children it will be diagnosed and treated early. I have recently been in contact with a young man who was diagnosed aged 30 shortly after he got married. Five years down the line he has fathered 2 children and competes in iron man competitions....and on diagnosis they fought to save his kidneys! So maybe it is not the end of the world should it be genetic. We are aware and if caught and treated early living a full life is a possibility

[drz]

If AI diseases are mainly caused by environmental poisons, there could be some family correlation since most family members generally share the same environment.

Is is generally unheard of in Japan? Is this due to failure to diagnose or actually lack of incidence. Maybe the Japanese have developed a higher tolerance to toxins from heavy exposures.

[Dryhill]

If AI diseases are mainly caused by environmental poisons, there could be some family correlation since most family members generally share the same environment.

Is is generally unheard of in Japan? Is this due to failure to diagnose or actually lack of incidence. Maybe the Japanese have developed a higher tolerance to toxins from heavy exposures.

From what I have read wg has a much higher incidence in caucasians (around 90%) than in other ethnic groups and is even less likely in Japan (around 3%), but this of course could be poor diagnosis. On the other hand the Japanese do eat a lot more fish than most westerners, could that be a reason?

The fact that AI diseases are increasing more in western civilisation could again be down to poor diagnosis or perhaps to do with environmental reasons (diet and pollution just to name two). As one can see we are not likely to get a quick answer to these questions even if we assume there is plenty of money available for such research.

[nessa]

thanx all for your reply s.. i really hope weggies isnt genetic. =)

[Al]

thanx all for your reply s.. i really hope weggies isnt genetic. =)

Again, the simple (and mostly accurate) answer is that it is not. In fact, no one knows for sure exactly why we get WG and other autoimmune diseases, though there are reasons to suspect that infections, environmental toxins, emotional stress, diet, sleeping patterns, and a lot of other things can put added stress onto the immune system, setting it up for something bad to happen. That doesn't mean that living a perfect life will let us avoid our disease, however. That would be too easy, and too untrue. Again, no one knows the specifics of how we get the disease; in any case, every case is different.

Al

Al

[jola57]

I think I mentioned tthis before but here it is. Same egg twins were brought up together thru II World War until 18th birthday in Poland then each emigrated to a different continent, one to Australia the other to Canada. Long story short the Canadian twin developed Parkinsons and passed away at age 70+, his twin is now in his 80 and healthy. Moral of the story, same genes different environmental , social environments and probably different nutrition played a significant role in these gentlemn's longevity. So eat healthy, excercise, get rid of stress and live a long healthy life and hey you down under, you seem to have a leg up on us North Americans. :flapper:

[mishb]

So eat healthy, excercise, get rid of stress and live a long healthy life and hey you down under, you seem to have a leg up on us North Americans. :flapper:

Yes, but unfortunately we also have WG in our midst........even down here :lol:

I have eleven brothers/sisters so out of twelve kids, I am the only one to have a handful of AI's.
There are other AI conditions amongst other family members but not within my immediate family, my kids or any of their kids (that I know of)

Nessa, I am pretty certain that you don't have to worry at all (and it can't be helping your own situation)

Take care and remember ..........

[Sangye]

Nessa, I'm a chiropractor who specialises in pediatrics. When my young patients had nosebleeds I'd ask them "Show me the finger you use to pick your nose!" They'd quickly hold up a finger. LOL If you ask a small child if they pick their nose they'll say no, because they know it's wrong. This little trick works every time.

I'm not saying it couldn't be Wegs, but the chances are exceedingly remote. Ask to see the nose-picking finger. :wink1: