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View Full Version : Acetylcysteine as Adjuvant Therapy for Vasculitis Associated with Antineutrophil Cyto



Palmyra
04-08-2011, 12:54 AM
http://jrheum.org/content/38/4/785.full

Has anyone heard of the fore mentioned drug? Just read this from a Vasculitis alert on my web browser.......

Sangye
04-08-2011, 01:20 AM
Very interesting and supports the theory that toxins can cause Wegs. Acetylcysteine is a commonly used supplement to assist with detoxification. Here's some info from Wikipedia: Acetylcysteine - Wikipedia, the free encyclopedia (http://en.wikipedia.org/wiki/Acetylcysteine)

Lightwarrior
04-09-2011, 08:33 AM
The brand name is Mucomsyt. We use it frequently when someone comes in with an overdose of acetaminophen (Tylenol), if we start it right away we can prevent some of the liver damage. We also use to protect liver and kidneys prior to sending someone off to the cardiac cath lab.

Daggar
04-09-2011, 09:19 AM
Palmyra -- Funny how things work -- I was reading Sangaye's and your link about Acetylcysteine and came across this other drug that Nephrologists are excited about -- Bardoxolone -- Has anyone heard of this?

It is being studied as a promising treatment for Chronic Kidney Disease - mostly in diabetics but I'm just curious if this drug could help WG patients with kidney involvement?

http://www.transplantbuddies.org/tbx/messages/7/Novel_Anti-Inflammatory_Bardoxolone_Improves_GFR_in_CKD-384086.pdf

drz
04-09-2011, 10:23 AM
Palmyra -- Funny how things work -- I was reading Sangaye's and your link about Acetylcysteine and came across this other drug that Nephrologists are excited about -- Bardoxolone -- Has anyone heard of this?

It is being studied as a promising treatment for Chronic Kidney Disease - mostly in diabetics but I'm just curious if this drug could help WG patients with kidney involvement?
http://www.transplantbuddies.org/tbx/messages/7/Novel_Anti-Inflammatory_Bardoxolone_Improves_GFR_in_CKD-384086.pdf


Thanks for posting this. Muscle spasms are very common side effect which doesn't sound good since I have enough of those all ready. I wonder why they said most were on ACE inhibitor and I was taken off that immediately and told I should never have been on it, but don't know why. I guess they thought it contributed to my kidney damage. Years ago they were pushing everyone with diabetes to be on one.

Daggar
04-09-2011, 11:05 AM
Not sure drz.... ACE inhibitors seem to be mentioned often with diabetes/kidney function....

I did find this though:

Individuals with bilateral renal artery stenosis (http://www.wegeners-granulomatosis.com/script/main/art.asp?articlekey=17313) (narrowing) may experience worsening of kidney function, and people who have had a severe reaction to ACE inhibitors probably should avoid them.

04-12-2011, 07:22 AM
I know 'Acetylcyste´ne' only as a cough medicine.


It is used as a cough medicine because it breaks disulfide bonds in mucus and liquefies it, making it easier to cough up.

(quote from Wikipedia)

Didn't know that it was used for detoxification...
Quite interesting!

Lightwarrior
04-12-2011, 07:36 AM
A cough syrup, it smells like rotten eggs.

pberggren1
04-12-2011, 10:59 AM
What about Buckleys?

Palmyra
04-12-2011, 01:21 PM
Lightwarrior! Just so happy to see your post (and yours too, Pberggeren!) God only knows what is coming down the pipeline for this disease, or what causes it. I think my daughter's use of TNF~alpha inhibitors provoked her Weg, as per suggested in medical literature, but she had no choice at the time. Looking for more drugs, more action, more leads to a cure!

Ahem,,, a good nod to you Lightwarrior/ peas to you.

And Phil, what is Buckleys?

pberggren1
04-12-2011, 03:06 PM
Buckleys is a cough syrup.

Lightwarrior
04-13-2011, 03:06 AM
Acetylcysteine as Adjuvant Therapy for Vasculitis Associated with Antineutrophil Cytoplasmic Antibody (http://jrheum.org/content/38/4/785.full)

Has anyone heard of the fore mentioned drug? Just read this from a Vasculitis alert on my web browser.......

Palmyra,
What a fascinating use for Acetylcysteine. They used the tablet form. I have not seen that so it probably doesn't taste like rotten eggs. If it would keep Wegs in remission we might learn to like rotten egg taste (lol)