I'm relapsing badly this weekend. A couple of months ago, a doctor prescribed prescription strength melatonin for my sleep disorder. It's been down hill ever since. Seeing my neurologist Tuesday, hoping to get a pred taper, until my RTX infusion at the end of the month.

Melatonin increases pro-inflammatory cytokines IL-12, IL-2 and IL-6

Il-2 promotes B cell proliferation.
IL-12 plays a role in antigen presentation
IL-6 serves a number of inflammatory functions.


And yes, I did discuss melatonin with my rheumy before taking it. She didn't think it would be a problem. I stopped melatonin yesterday. It's forever off my list.