User Tag List

Likes Likes:  8
Results 1 to 9 of 9

Thread: Methotrexate vs Imuran?

  1. #1
    Join Date
    Mar 2016
    Location
    Oklahoma City, OK
    Posts
    9
    Post Thanks / Like
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default Methotrexate vs Imuran?

    Hello,

    I am currently taking Prednisone and Plaquinil for to keep my Wegener's symptoms in check. However, I have been trying to ween down off of Prednisone (pre-diabetes and just over all Prednisone ick) - but can't seem to get all the way off due to pretty bad joint pain. Also showing some decreased kidney function. Doc wants me to consider Methotrexate or Imuran. I have not had experience with either of these drugs, and would love to hear from those of you who have. What should I expect as far as side effects, etc.

  2. #2
    Join Date
    Oct 2011
    Location
    near Phx, AZ
    Posts
    1,742
    Post Thanks / Like
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    Hi Rachel, your pred experience is pretty common. It's not easy for many people to wean off pred. Took me a couple of long efforts to make it. As your 'other' choice of meds kicks in, the pred will be needed less. I was on Methotrexate the entire time. Took about 3-4 years to get rid of that too! Side effects of MTX are mild for the most part...doc had me split dosage times to help avoid some of the effects. My worst one was hair loss...lol...extra folic acid took care of that. Best to you, follow your protocols!!!
    Knowing how to think empowers you far beyond those who only know what to think. -NdT


  3. Likes Jaha, Alysia liked this post
  4. #3
    Join Date
    Nov 2014
    Location
    Central Pennsylvania
    Posts
    180
    Post Thanks / Like
    Mentioned
    5 Post(s)
    Tagged
    0 Thread(s)

    Default

    I had taken them seperately, and then together for 10 years. I prefer imuran as far as side effects. I was a stable slightly more tired, where with the methotrexate i got kicked pretty hard the day after i took it every week. Thats my 10 cents, but you won't really know how your own body will respond until you do it, unfortunately.

  5. Likes Jaha liked this post
  6. #4
    Join Date
    Mar 2016
    Location
    Oklahoma City, OK
    Posts
    9
    Post Thanks / Like
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    I'm worried about the hair loss. I had terrible hair loss with cytoxan - to the point I had to just shave it - and have alopecia problems already. Thanks for the input!

  7. #5
    Join Date
    Mar 2016
    Location
    Oklahoma City, OK
    Posts
    9
    Post Thanks / Like
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    Thanks - Ill keep that in mind. I have pretty bad fatigue problems as is.

  8. #6
    Join Date
    Nov 2014
    Location
    Central Pennsylvania
    Posts
    180
    Post Thanks / Like
    Mentioned
    5 Post(s)
    Tagged
    0 Thread(s)

    Default

    Wow Rachel, I see in your profile you have had wegs quite awhile!!! Can you share your story of how you got dxed? I wonder, if the cytoxen was administered differently back then, and thats why the hair loss? But maybe you have had it more recently. I was dxed at 16, and i'm 33 now. I only had cytoxen for 4 months.

  9. #7
    Join Date
    Mar 2016
    Location
    Oklahoma City, OK
    Posts
    9
    Post Thanks / Like
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    I was 16 when diagnosed as well. I had suffered from bad sinus infections for awhile, but then started getting random joint pain and an elevated SED rate. While waiting to see a Rheumatologist I started coughing up blood - and that really sped up the whole process. I ended up having kidney, lung and sinus involvement, and I wound up spending some time in the hospital on IV prednisone treatment. Thats when they started me on the cytoxan. I can't remember the dosage, but it was just an oral pill. They didn't expect me to lose my hair or anything, but I had bad hair loss and it sent me into early menopause. I also ended up staying on the cytoxan for way too long. Because of insurance changes, I had to stop seeing my diagnosing doc and the new doc kept me on the cytoxan for 2-3 years. I ended up with neutropenic fever because of it. The hair loss happened pretty quickly after starting the treatment though - so that's why that worries me with these other meds.
    You're one of the few people I've encountered that was diagnosed at a young age as well. How have you gotten along over the years? Any big flares?

  10. #8
    Join Date
    Jul 2014
    Location
    Anchorage, Alaska
    Posts
    238
    Post Thanks / Like
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    I have only taken MTX as my primary maintenance drug, so can't compare with Imuran. I do know that MTX is generally well tolerated and I have not had any big problems with it. I did experience some hair thinning and slower than normal hair growth after haircuts for a while. That still seems sort of variable and maybe is influenced by other factors too, like time of year and amount of sunlight. (I live in Alaska.) But, it's never been noticeable to anyone but myself and the person who cuts my hair. Anyway, I believe many docs consider it to be one of the least toxic maintenance meds. I have had some occasional mild nausea, some elevation of liver enzymes on labs, but nothing alarming.

    Quote Originally Posted by Rachel_Elise View Post
    Hello,

    I am currently taking Prednisone and Plaquinil for to keep my Wegener's symptoms in check. However, I have been trying to ween down off of Prednisone (pre-diabetes and just over all Prednisone ick) - but can't seem to get all the way off due to pretty bad joint pain. Also showing some decreased kidney function. Doc wants me to consider Methotrexate or Imuran. I have not had experience with either of these drugs, and would love to hear from those of you who have. What should I expect as far as side effects, etc.

  11. Likes Rachel_Elise liked this post
  12. #9
    Join Date
    May 2014
    Location
    Bristol, IN
    Posts
    31
    Post Thanks / Like
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    Quote Originally Posted by Rachel_Elise View Post
    Hello,

    I am currently taking Prednisone and Plaquinil for to keep my Wegener's symptoms in check. However, I have been trying to ween down off of Prednisone (pre-diabetes and just over all Prednisone ick) - but can't seem to get all the way off due to pretty bad joint pain. Also showing some decreased kidney function. Doc wants me to consider Methotrexate or Imuran. I have not had experience with either of these drugs, and would love to hear from those of you who have. What should I expect as far as side effects, etc.
    Rachel, I have taken Imuran since going off cytoxin. I lost most of my hair when on cytoxin, but have had no hair loss with Imuran. I have been on it about 8 years now with no significant side effects and I have not had a flare. I have tried to cut down the amount twice, with my doctor's approval, but both times symptoms came back. I'm thinking about trying it again, though. I have not been on any prednisone since I was weaned off. So far so good! ☺

    Sent from my SM-T800 using Tapatalk
    ----Arleta




  13. Likes Pete, Rachel_Elise, Jaha, Alysia liked this post

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •